4LTE: Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor

PDB ID: 4LTEDownload
MMDB ID: 245997
PDB Deposition Date: 2013/7/23
Updated in MMDB: 2024/04
Experimental Method:
x-ray diffraction
Resolution: 2.705  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 4LTE: dimeric; determined by author and by software (PISA)
Molecular Components in 4LTE
Label Count Molecule
Proteins (2 molecules)
1
Insulin-degrading Enzyme
Molecule annotation
1
Macrocyclic Inhibitor
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
ZINC IONZINC ION
2
1
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
3
1
2,6-DIAMINO-HEXANOIC ACID AMIDE2,6-DIAMINO-HEXANOIC ACID AMIDE
4
1
FUMARIC ACIDFUMARIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303