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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
In general, laser therapy and phototherapy are considered acceptable during breastfeeding.[1,2] Phototherapy for psoriasis is also generally acceptable; however, nursing should be withheld for 24 hours after ingestion of an oral psoralen, such as methoxsalen.[3]
Laser therapy was used in some Russian and Austrian studies to prevent and treat lactation mastitis and nipple fissures.[4-8] However, these studies are rather old and not well controlled. Two more recent, well-controlled studies found somewhat conflicting results. In one, laser light applied to the nipple improved the pain from nipple lesions one day sooner than sham therapy.[9] In the other, a single application of laser light resulted in no difference in nipple pain during the first 24 hours after application.[10]
Some small studies have found that application of laser light to the breasts increases serum prolactin and milk production. Laser application to cesarean section wounds did not adversely affect serum prolactin.[11]
A study from China indicated that high-intensity red light (630 nM) plus antibiotics were more effective than antibiotics alone in healing mastitis and preventing recurrence.[12] Laser light has also been used as part of a 5-step procedure to treat mastitis.[13]
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Use of low-level laser therapy to enhance healing of the surgical incision following cesarean section was evaluated in a small, poorly controlled study. Laser light was applied for 15 minutes on 3 consecutive days postoperatively. On the third day, serum prolactin levels were not significantly different in the two groups. The treatment appeared to help wound healing.[11]
A small, randomized study compared primiparous mothers who were supplementing their infants with formula during the first month postpartum and who received either 12 sessions of low-level laser light to the breasts over 3 weeks (n = 20) or no treatment (n = 20). All mothers received similar counseling by a blinded physician certified in lactation counseling. The treated group had greater increases in serum prolactin, and breastmilk lactose, protein and fat at 3 weeks and 3 months after the start of therapy.[14]
A randomized study of women (n = 20 in each group) who were mixed feeding their infants in the first month postpartum compared 12 session of electroacupuncture or low-level laser therapy to the breast over 1 month and control women. All women also received oral domperidone 10 mg three times daily. Laser therapy increased serum prolactin, infant weight and maternal perception of milk production more than domperidone alone, but less than electroacupuncture.[15]
References
- 1.
- Lee KC, Korgavkar K, Dufresne RG, Jr, Higgins HW, 2nd. Safety of cosmetic dermatologic procedures during pregnancy. Dermatol Surg 2013;39:1573-86. [PubMed: 24164677]
- 2.
- Yaghi M, McMullan P, Truong TM, et al. Safety of dermatologic medications in pregnancy and lactation: An Update - Part II: Lactation. J Am Acad Dermatol 2024. [PubMed: 38280680]
- 3.
- Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 2010;62:114-35. [PubMed: 19811850]
- 4.
- Dotsenko AP, Chinchenko EI, Khodos VA. [Use of carbon dioxide laser in the treatment of acute lactation mastitis]. Sov Med 1989;(9):39-42. [PubMed: 2513650]
- 5.
- Kovalev MI. [Prevention of lactation mastitis by the use of low-intensity laser irradiation]. Akush Ginekol (Mosk) 1990;(2):57-61. [PubMed: 2339766]
- 6.
- Skobelkin OK, Brekhov EI, Chegin VM, et al. [The carbon dioxide laser in the complex treatment of acute suppurative lactation mastitis]. Vestn Khir Im I I Grek 1984;132:67-9. [PubMed: 6424314]
- 7.
- Skobelkin OK, Derbenev VA, Velikii PIa, Tsyganova GI. [Use of lasers in the treatment of acute suppurative lactation mastitis]. Vestn Khir Im I I Grek 1988;141:46-9. [PubMed: 3149064]
- 8.
- Pietschnig B, Pani M, Kafer A, et al. Use of soft laser in the therapy of sore nipples in breastfeeding women. Adv Exp Med Biol 2000;478:437-8. [PubMed: 11065120]
- 9.
- Coca KP, Marcacine KO, Gamba MA, et al. Efficacy of low level laser therapy in relieving nipple pain in breastfeeding women: A triple-blind, randomized, controlled trial. Pain Manag Nurs 2016;17:281-9. [PubMed: 27363734]
- 10.
- Camargo BTS, Coca KP, Amir LH, et al. The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial. Lasers Med Sci 2020;35:63-9. [PubMed: 31030379]
- 11.
- Mokmeli S, Khazemikho N, Niromanesh S, Vatankhah Z. The application of low-level laser therapy after cesarean section does not compromise blood prolactin levels and lactation status. Photomed Laser Surg 2009;27:509-12. [PubMed: 19405857]
- 12.
- Miao M, Fan CN, Liu N, Sun G. Clinical application research on the use of carnation photon therapeutic apparatus in treatment for acute postpartum mastitis. Proc 2016 Int Conf Biol Sci Technol 2016:154-7.
- 13.
- Yao Y, Long T, Pan Y, et al. A 5-step systematic therapy (FSST) for treating plugged ducts and mastitis in breastfeeding women: A case control study. Asian Nurs Res (Korean Soc Nurs Sci) 2021;15:197-202. [PubMed: 34048977]
- 14.
- El Taweel A, Yousef A, Hasanin M, et al. Effect of low level laser therapy of the breasts on milk production and composition in supplement dependent mothers. Breastfeed Med 2017;12 (Suppl 1):S13. doi:10.1089/bfm.2017.29058.abstracts [CrossRef]
- 15.
- Maged AM, Hassanin ME, Kamal WM, et al. Effect of low-level laser therapy versus electroacupuncture on postnatal scanty milk secretion: A randomized controlled trial. Am J Perinatol 2020;37:1243-9. [PubMed: 31327162]
Substance Identification
Substance Name
Phototherapy
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- Review [Narrow-band UVB therapy in psoriasis vulgaris: good practice guideline and recommendations of the French Society of Photodermatology].[Ann Dermatol Venereol. 2010]Review [Narrow-band UVB therapy in psoriasis vulgaris: good practice guideline and recommendations of the French Society of Photodermatology].Beani JC, Jeanmougin M. Ann Dermatol Venereol. 2010 Jan; 137(1):21-31. Epub 2009 Dec 29.
- Comparative evaluation of NBUVB phototherapy and PUVA photochemotherapy in chronic plaque psoriasis.[Indian J Dermatol Venereol Lep...]Comparative evaluation of NBUVB phototherapy and PUVA photochemotherapy in chronic plaque psoriasis.Dayal S, Mayanka, Jain VK. Indian J Dermatol Venereol Leprol. 2010 Sep-Oct; 76(5):533-7.
- Narrowband UV-B (TL-01) phototherapy vs oral 8-methoxypsoralen psoralen-UV-A for the treatment of chronic plaque psoriasis.[Arch Dermatol. 2003]Narrowband UV-B (TL-01) phototherapy vs oral 8-methoxypsoralen psoralen-UV-A for the treatment of chronic plaque psoriasis.Markham T, Rogers S, Collins P. Arch Dermatol. 2003 Mar; 139(3):325-8.
- Lenticular psoralen photoproducts and cataracts of a PUVA-treated psoriatic patient.[Arch Dermatol. 1985]Lenticular psoralen photoproducts and cataracts of a PUVA-treated psoriatic patient.Woo TY, Wong RC, Wong JM, Anderson TF, Lerman S. Arch Dermatol. 1985 Oct; 121(10):1307-8.
- Review Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis.[Cochrane Database Syst Rev. 2013]Review Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis.Chen X, Yang M, Cheng Y, Liu GJ, Zhang M. Cochrane Database Syst Rev. 2013 Oct 23; 2013(10):CD009481. Epub 2013 Oct 23.
- Phototherapy - Drugs and Lactation Database (LactMed®)Phototherapy - Drugs and Lactation Database (LactMed®)
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