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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 33671-46-4
Drug Levels and Effects
Summary of Use during Lactation
Clotiazepam is not approved for marketing in the United States by the U.S. Food and Drug Administration. Very little information is available on the passage of clotiazepam into milk. One review recommends avoiding clotiazepam during breastfeeding.[1] An alternate drug is preferred, especially while nursing a newborn or preterm infant. If clotiazepam is used, monitor the infant for sedation, poor feeding and poor weight gain.
Drug Levels
Maternal Levels. A woman who was taking oral clotiazepam 5 mg daily donated a milk sample between 3 and 6 days postpartum at 1 hour after a dose at the estimated peak serum concentration. She had a 1-hour milk level of 16.3 mcg/L.[2]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Bascoul C, Franchitto L, Parant O, et al. [Psychotropic drugs during pregnancy and lactation: Development practice]. Presse Med 2015;44:271–83. [PubMed: 25595818]
- 2.
- Nishimura A, Furugen A, Umazume T, et al. Benzodiazepine concentrations in the breast milk and plasma of nursing mothers: Estimation of relative infant dose. Breastfeed Med 2021;16:424-31. [PubMed: 33449825]
Substance Identification
Substance Name
Clotiazepam
CAS Registry Number
33671-46-4
Drug Class
Breast Feeding
Milk, Human
Hypnotics and Sedatives
Anti-Anxiety Agents
Benzodiazepines
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- cell division control protein 42 homolog isoform 1 precursor [Homo sapiens]cell division control protein 42 homolog isoform 1 precursor [Homo sapiens]gi|89903012|ref|NP_001034891.1|Protein
- Homo sapiensHomo sapiensRefSeq annotation of the human reference genome assemblyBioProject
- BioProject Links for Protein (Select 2217275476) (1)BioProject
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