GPL16397[Accession] - GEO DataSets

Select item 2000430131.

Gene Expression Defines Natural Changes in Mammalian Lifespan

(Submitter supplied) Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. more...

Organism:: Chlorocebus aethiops; Felis catus; Bos taurus; Capra hircus; Oryctolagus cuniculus; Rattus norvegicus; Erinaceus europaeus; Suncus murinus; Canis lupus familiaris; Peromyscus leucopus; Acomys cahirinus; Cavia porcellus; Tamias sibiricus; Tadarida brasiliensis; Ursus americanus; Meles meles; Equus caballus; Mesocricetus auratus; Meriones unguiculatus; Sus scrofa; Mus musculus; Petaurus breviceps; Murina leucogaster

Type:: Expression profiling by high throughput sequencing

23 related Platforms
141 Samples

Download data: GTF, TXT

Series

Accession:: GSE43013

ID:: 200043013

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000488312.

Viral small RNAs in Sindbis virus-infected mammalian cells

(Submitter supplied) Small RNAs play a critical role in host-pathogen interaction. In insects, for instance, small RNA-mediated silencing or RNA interference (RNAi) represents the main antiviral defense system. However, the antiviral role of RNAi has not been clearly proven in higher vertebrates. On the contrary, it is well established that the cell response relies on the recognition of viral RNAs by host pattern recognition receptors (PRR) to trigger the activation of the interferon pathway. more...