GEO DataSets

(Submitter supplied) GeneChip Human Transcriptome Array 2.0 of sorted T cells from human tonsils or follicular lymphoma

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17585 GPL17586

48 Samples

Download data: CEL, CHP

(Submitter supplied) Polo-like kinase 1 (PLK1), a serine/threonine kinase and important cell cycle regulator, is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB, a NOTCH antagonist. However, the exact role of PLK1-NUMB-NOTCH axis in epithelial-mesenchymal transition (EMT) and melanoma progression is unclear. In this study, Affymetrix microarray analysis was performed to determine differentially expressed genes following doxycyclin induced shRNA-mediated knockdown of PLK1 in human melanoma cells that showed significant modulations in EMT and metastasis related genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

8 Samples

Download data: CEL, CHP, XLSX

(Submitter supplied) We used the Human Transcriptome Array 2.0 expression data to examine quality control, reproducibility, and insights on differential gene expression inflammatory breast cancer biopsy specimens prior to systemic treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

10 Samples

Download data: CEL, CHP

(Submitter supplied) In undifferentiated human ES cells, 5hr Met deprivation (delta Met) led to decreased proliferation, and promote differentiation We used microarrays to detail the mollecular mechanism of cell-death caused by Met deprivation in undifferentiated iPS cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

10 Samples

Download data: CEL, CHP, XLSX

(Submitter supplied) Isoginkgetin (IGG) is a small molecule inhibitor of the spliceosome although the direct target remains elusive. Widespread failure to accurately remove introns poses a risk to cells and organisms through the potential production of aberrant mRNAs and proteins. The cellular responses to accumulation of these intermediates and/or the direct interference of spliceosome assembly itself may constitute a splicing stress but this is not well defined yet. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17586 GPL17585

24 Samples

Download data: CEL, CHP

(Submitter supplied) We investigated transcriptome alterations in the prefrontal cortex (BA) of patients with Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) when compared with elderly controls without neurological or psychiatric diseases (CTRL) using Affymetrix Human Transcriptome Array 2.0 All brain samples were provided by the Brains for Dementia Research (BDR), UK. All cases were prospectively assessed by experienced clinicians using validated clinical rating instruments. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

42 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL23976 GPL17585

8 Samples

Download data: CEL, CHP, IDAT, TXT

(Submitter supplied) Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis involves both genetic and environmental factors. DNA methylation, the most studied epigenetic modification, was shown to play a role in IgAN. In two pairs of IgAN-discordant monozygotic (MZ) twins, here we assessed genome-wide DNA methylation profiling and gene expression profiling in order to characterize DNA methylation changes in IgAN and their potential influences on gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

4 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Gene expression signature can be used to predict treatment efficacy in various types of tumour. We aim to identify a gene expression signature to predict efficacy of induction chemotherapy (IC) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

95 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17586 GPL20301 GPL17585

890 Samples

Download data: CEL

(Submitter supplied) We systematically investigated the transcriptomic response pattern of PBMC from 41 patients with IBD to characterize relevant stimuli that target different aspects of innate and adaptive immune cell responses. Lipopolysaccharide(LPS), muramyl-dipeptide (L18MDP), T cell receptor and co-stimulation (αCD3/αCD28 coated beads), and IL-10 signalling blockade were used to sitmulate subject PBMC's alone or in combination based on the concept that innate pathogen recognition receptor responses (in particular NOD2 and TLR4), T cell responses, and IL-10 signalling defects are implicated by multiple genetic IBD susceptibility loci and Mendelian forms of IBD.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17585 GPL17586

886 Samples

Download data: CEL

(Submitter supplied) We analysed gene expression levels in a panel of pharmacologically patient derived glioblastoma cell lines. The purpose of the experiment was to provide gene expression data for predictive modeling of drug responses. For more information about the Human Glioma Cell Culture (HGCC) resource, see portal.hgcc.se.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

145 Samples

Download data: CEL, TXT

(Submitter supplied) In this data, we examined Transcriptome detection and expression in 8 samples of Retinoblastoma. We found a central core shared by all samples . We used exon arrays to find a detected and undetected transcripts and genes in Retinoblastoma and we compared unilateral and bilateral samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

8 Samples

Download data: CEL, CHP

(Submitter supplied) HTA2.0 affy array was used to study the effect of androgen inhibitors on alternative splicing in LNCaP cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

9 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL17585 GPL16791

23 Samples

Download data: BIGWIG, CEL, CHP

(Submitter supplied) Increasing evidence suggests that tRNA levels are dynamically and specifically regulated in response to internal and external cues to modulate the cellular translational program. However, the molecular players and the mechanisms regulating the gene-specific expression of tRNAs are still unknown. Using an inducible auxin-degron system to rapidly deplete RPB1 (the largest subunit of RNA Pol II) in living cells, we identified Pol II as a direct gene-specific regulator of tRNA transcription. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

7 Samples

Download data: CEL, CHP, CSV

(Submitter supplied) Deletion (Del) of 17p involving the TP53 tumor suppressor remains an adverse prognostic factor in multiple myeloma, and more effective targeted therapies are needed for these patients. Genomic studies revealed that del17p was associated with reduced copy number and mRNA expression of RNA polymerase II subunit alpha (POLR2A), which is located near TP53. We therefore studied HDP-101, an anti-B-cell maturation antigen (BCMA) antibody drug conjugate (ADC) with the POLR2A poison α-amanitin, which showed potent anti-proliferative and pro-apoptotic activity against cell lines and primary samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

32 Samples

Download data: CEL, CHP

(Submitter supplied) The most fatal primary brainstem tumors in pediatric patients are diffuse intrinsic pontine gliomas (DIPGs). The identification of genetic alterations, such as the H3K27M mutation, allows a better molecular classification of these tumors. Therefore, the identification of new molecular features, mediating their formation and progression, as non-coding RNAs (ncRNAs), would be of great importance for the development of effective treatments.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL17585 GPL17586

12 Samples

Download data: CEL, CHP

(Submitter supplied) It’s a well-established fact that epigenetic changes regulate alternative splicing in a context-dependent manner, as well as the epigenetic modifying effect of curcumin, is known in cancer. In this study, we have investigated the role of curcumin in the regulation of alternative splicing through epigenetic alterations. We performed Human Transcriptome Array 2.0 to understand the global changes in gene expression as well as alternative splicing upon curcumin-PEC treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

4 Samples

Download data: CEL, CHP

(Submitter supplied) THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. Here we show that human THO interacts with MFAP1, a spliceosome-associated factor. Interestingly, MFAP1 depletion impairs cell proliferation and genome integrity, increasing γH2AX foci and DNA breaks. This phenotype is not dependent either on transcription or RNA-DNA hybrids. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17585 GPL17586

18 Samples

Download data: CEL, CHP