GEO DataSets

(Submitter supplied) Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development remain elusive. We analyzed 1,745 spontaneous pregnancy losses and found that roughly half (50.4%) of the products of conception (POC) were karyotypically abnormal, with maternal and paternal age independently contributing to the increased genomic aberration rate in pregnancy loss. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array; Genome variation profiling by array

Platforms:

GPL28939 GPL21145

463 Samples

Download data: IDAT

(Submitter supplied) Extensive genome analysis of pregnancy loss products by genome haplarithmisis. Pregnancy loss (PL) is the primary pregnancy complication, mostly caused by chromosomal abnormalities of the conceptus. However, the nature and prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental compartments during intrauterine development remains elusive. We analyzed 1,745 spontaneous PLs and found that ~50% were karyotypically normal. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL28939

450 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome variation profiling by SNP array

Platforms:

GPL24676 GPL28939

1179 Samples

Download data: CSV, IDAT, TXT

(Submitter supplied) The human immune system displays remarkable variation between individuals, leading to differences in susceptibility to autoimmune disease. We present single cell RNA sequence data from 1,267,768 peripheral blood mononuclear cells from 982 healthy human subjects. For 14 cell types, we identified 26,597 independent cis-expression quantitative trait loci (eQTLs) and 990 trans-eQTL, with the majority showing cell type specific effects on gene expression. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL28939

1104 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome variation profiling by SNP array

Platforms:

GPL28939 GPL24676

16 Samples

Download data: IDAT, TXT

(Submitter supplied) Testicular cancer (TC) is the most common solid tumour in young men. While cisplatin-based chemotherapy is highly effective in TC patients, chemoresistance still accounts for 10% of disease-related deaths. Pre-clinical models that faithfully reflect patient tumours are needed to assist in target discovery and drug development. Tumour pieces from eight TC patients were subcutaneously implanted in NOD scid gamma (NSG) mice. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL28939

10 Samples

Download data: IDAT, XLSX

(Submitter supplied) An economical next-generation genotyping array that enables population-scale genetics, translational research, variant screening studies, and precision medicine research by combining highly optimized multiethnic genome-wide content, curated clinical research variants, and QC markers. With content from a variety of resources, this multiethnic array allows researchers to detect both common and rare variants across the most commonly studied 5 superpopulations in order to impute variants in a vast number of subpopulations. more...

Organism:

Homo sapiens

6 Series

1564 Samples

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