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Items: 8

1.

Ternary protein•drug•RNA interface explains RocA sequence selectivity and Aglaia resistance

(Submitter supplied) A novel class of translation inhibitors isolated from Aglaia plants, exemplified by Rocaglamide A (RocA), shows promise as an anti-cancer therapy. RocA converts its molecular target, translation initiation factor 4A (eIF4A), a DEAD-box protein, into a purine-selective RNA-binding protein that represses protein synthesis from a subset of mRNAs. This unusual mechanism of action raises the question of how the drug induces selectivity for polypurine sequences. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE102720
ID:
200102720

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
8771 Series
200001 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

3.

ribo_aglaiacized_roca

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743738
ID:
302743738

SRA Run Selector

4.

ribo_aglaiacized_DMSO_rep2

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743737
ID:
302743737

SRA Run Selector

5.

ribo_aglaiacized_DMSO_rep1

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743736
ID:
302743736

SRA Run Selector

6.

ribo_naive_roca

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743735
ID:
302743735

SRA Run Selector

7.

ribo_naive_DMSO_rep2

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743734
ID:
302743734

SRA Run Selector

8.

ribo_naive_DMSO_rep1

Organism:
Homo sapiens
Source name:
HEK293T-REx
Platform:
GPL20301
Series:
GSE102720
Download data: TXT
Sample
Accession:
GSM2743733
ID:
302743733

SRA Run Selector

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db=gds|term=GSE102720[Accession]|query=1|qty=2|blobid=MCID_67db4d8de6bb294013441a6a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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