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Items: 20

1.

ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models

(Submitter supplied) Hepatocellular carcinoma (HCC) currently lacks effective therapies, leaving a critical need for new treatment options. A previous study identified the Anaplastic Lymphoma Kinase (ALK) amplification in HCC patients, raising the question of whether ALK inhibitors could be a viable treatment. Here, we showed that both ALK inhibitors and ALK knockout effectively halted HCC growth in cell cultures. Lorlatinib, a potent ALK inhibitor, suppressed HCC tumor growth and metastasis across various mouse models. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
18 Samples
Download data: TXT
2.

Illumina HiSeq 3000 (Homo sapiens)

Platform
Accession:
GPL21290
ID:
100021290
3.

SNU-449 ALK targeted inhibition cells (Replicate_3)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384486
ID:
305384486
4.

SNU-449 ALK targeted inhibition cells (Replicate_2)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384485
ID:
305384485
5.

SNU-449 ALK targeted inhibition cells (Replicate_1)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384484
ID:
305384484
6.

SNU-449 Non-Target Expressing cells (Replicate_3)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384483
ID:
305384483
7.

SNU-449 Non-Target Expressing cells (Replicate_2)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384482
ID:
305384482
8.

SNU-449 Non-Target Expressing cells (Replicate_1)

Organism:
Homo sapiens
Source name:
SNU-449 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384481
ID:
305384481
9.

SK-HEP1 ALK targeted inhibition cells (Replicate_3)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384480
ID:
305384480
10.

SK-HEP1 ALK targeted inhibition cells (Replicate_2)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384479
ID:
305384479
11.

SK-HEP1 ALK targeted inhibition cells (Replicate_1)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384478
ID:
305384478
12.

SK-HEP1 Non-Target Expressing cells (Replicate_3)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384477
ID:
305384477
13.

SK-HEP1 Non-Target Expressing cells (Replicate_2)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384476
ID:
305384476
14.

SK-HEP1 Non-Target Expressing cells (Replicate_1)

Organism:
Homo sapiens
Source name:
SK-HEP1 cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384475
ID:
305384475
15.

HepG2/C3A ALK targeted inhibition cells (Replicate_3)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384474
ID:
305384474
16.

HepG2/C3A ALK targeted inhibition cells (Replicate_2)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384473
ID:
305384473
17.

HepG2/C3A ALK targeted inhibition cells (Replicate_1)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384472
ID:
305384472
18.

HepG2/C3A Non-Target Expressing cells (Replicate_3)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384471
ID:
305384471
19.

HepG2/C3A Non-Target Expressing cells (Replicate_2)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384470
ID:
305384470
20.

HepG2/C3A Non-Target Expressing cells (Replicate_1)

Organism:
Homo sapiens
Source name:
HepG2/C3A cell lines
Platform:
GPL21290
Series:
GSE178211
Download data
Sample
Accession:
GSM5384469
ID:
305384469
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