GSE21975[Accession] - GEO DataSets - NCBI

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Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases

(Submitter supplied) Messenger RNAs are regulated by a variety of degradation mechanisms in mammalian cells. In the canonical animal microRNA pathway, microRNAs in complex with Argonaute proteins bind to many mRNA targets with imperfect complementarity, leading to degradation of the mRNA through the regular decay machinery. The ancestral “slicer” endonuclease activity of Argonaute2 itself, which requires more extensive complementarity with the target RNA, is not used in this pathway, and has only been observed in two microRNA-guided cases. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL9115 GPL9250
27 Samples

Series

Accession:: GSE21975

ID:: 200021975

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000092502.

Illumina Genome Analyzer II (Mus musculus)

Organism:: Mus musculus

801 Series
5952 Samples

Platform

Accession:: GPL9250

ID:: 100009250

Select item 1000091153.

Illumina Genome Analyzer II (Homo sapiens)

Organism:: Homo sapiens

755 Series
6121 Samples

Platform

Accession:: GPL9115

ID:: 100009115

Select item 3005464644.

DroshaflflES_Tam_rep2

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546464

ID:: 300546464

SRA Run Selector

Select item 3005464635.

DroshaflflES_Tam_rep1

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546463

ID:: 300546463

SRA Run Selector

Select item 3005464626.

DroshaflflES_NoTam_rep2

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546462

ID:: 300546462

SRA Run Selector

Select item 3005464617.

DroshaflflES_NoTam_rep1

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546461

ID:: 300546461

SRA Run Selector

Select item 3005464608.

Ago2ko_ES_rep10

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546460

ID:: 300546460

SRA Run Selector

Select item 3005464599.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546459

ID:: 300546459

SRA Run Selector

Select item 30054645810.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546458

ID:: 300546458

SRA Run Selector

Select item 30054645711.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546457

ID:: 300546457

SRA Run Selector

Select item 30054645612.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546456

ID:: 300546456

SRA Run Selector

Select item 30054645513.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546455

ID:: 300546455

SRA Run Selector

Select item 30054645414.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546454

ID:: 300546454

SRA Run Selector

Select item 30054645315.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546453

ID:: 300546453

SRA Run Selector

Select item 30054645216.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546452

ID:: 300546452

SRA Run Selector

Select item 30054645117.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546451

ID:: 300546451

SRA Run Selector

Select item 30054645018.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546450

ID:: 300546450

SRA Run Selector

Select item 30054644919.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546449

ID:: 300546449

SRA Run Selector

Select item 30054644820.

Organism:: Mus musculus

Source name:: embryonic stem cells

Platform:: GPL9250
Series:: GSE21975

Sample

Accession:: GSM546448

ID:: 300546448

SRA Run Selector

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