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Items: 14

1.

Enhancer Remodeling-Driven Mevalonate Pathway Confers Resistance to KRAS Inhibitor in Colorectal Cancer

(Submitter supplied) This study investigates the resistance mechanisms to pan-KRAS inhibitors in colorectal cancer (CRC). We established a panel of patient-derived organoids (PDOs) and cell lines with differential sensitivity to pan-KRAS inhibitors. Integrated epigenomic (ChIP-seq for H3K27ac and H3K4me3) and transcriptomic (RNA-seq) profiling revealed that enhancer remodeling drives compensatory activation of the mevalonate (MVA) pathway in resistant models. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL20301
12 Samples
Download data: BW, XLSX
Series
Accession:
GSE306909
ID:
200306909

2.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
9272 Series
214449 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

3.

LS174T-R_H3K4me3,LS174T resistant, H3K4me3 ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212128
ID:
309212128

SRA Run Selector

4.

LS174T-R_H3K4me3-input,LS174T resistant, H3K4me3-input ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212127
ID:
309212127

SRA Run Selector

5.

LS174T-P_H3K4me3,LS174T parental, H3K4me3 ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212126
ID:
309212126

SRA Run Selector

6.

LS174T-P_H3K4me3-input,LS174T parental, H3K4me3-input ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212125
ID:
309212125

SRA Run Selector

7.

LS174T-R_H3K27ac LS174T resistant, H3K27ac ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212124
ID:
309212124

SRA Run Selector

8.

LS174T-R_H3K27ac-input,LS174T resistant, H3K27ac-input ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212123
ID:
309212123

SRA Run Selector

9.

LS174T-P_H3K27ac,LS174T parental, H3K27ac ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212122
ID:
309212122

SRA Run Selector

10.

LS174T-P_H3K27ac-input,LS174T parental, H3K27ac-input ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212121
ID:
309212121

SRA Run Selector

11.

LS174T-R_rep2,LS174T resistant,Biological Rep 2

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data
Sample
Accession:
GSM9212120
ID:
309212120

SRA Run Selector

12.

LS174T-R_rep1,LS174T resistant, Biological Rep 1

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data
Sample
Accession:
GSM9212119
ID:
309212119

SRA Run Selector

13.

LS174T-P_rep2, LS174T parental, Biological Rep 2

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data
Sample
Accession:
GSM9212118
ID:
309212118

SRA Run Selector

14.

LS174T-P_rep1, LS174T parental, Biological Rep 1

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data
Sample
Accession:
GSM9212117
ID:
309212117

SRA Run Selector

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