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Items: 8

1.

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(Submitter supplied) Aging and its physiological manifestations have been correlated with adult stem cell exhaustion and a failure to maintain tissue homeostasis1-10. Since multiple morphological cellular defects are associated with aging-related disorders, we hypothesized that late onset disorders might be linked to adult stem cell abnormalities compromising cellular function over time. Our work shows that a dominant G2019S mutation in the human LRRK2 gene, which is associated with central nervous system disorders, including Parkinson’s disease, the second most prevalent neurodegenerative disease in the aging population, causes alterations in neural stem cell homeostasis in aging-related cellular contexts. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: BED, BW
Series
Accession:
GSE34061
ID:
200034061

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

LK2(GS/GS)-ipsNSC(p15)

Organism:
Homo sapiens
Source name:
iPSC-derived NSCs bearing homozygous LRRK2(G2019S) mutation at passage 15
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841176
ID:
300841176

SRA Run Selector

4.

LK2(GS/GS)-ipsNSC(p10)

Organism:
Homo sapiens
Source name:
iPSC-derived NSCs bearing homozygous LRRK2(G2019S) mutation at passage 10
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841175
ID:
300841175

SRA Run Selector

5.

LK2(+/+)-ipsNSC(p15)

Organism:
Homo sapiens
Source name:
wild-type iPSC-derived NSCs at passage 15
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841174
ID:
300841174

SRA Run Selector

6.

LK2(+/+)-ipsNSC(p10)

Organism:
Homo sapiens
Source name:
wild-type iPSC-derived NSCs at passage 10
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841173
ID:
300841173

SRA Run Selector

7.

LK2(GS/GS)-iPSC

Organism:
Homo sapiens
Source name:
iPSCs bearing homozygous LRRK2(G2019S) mutation
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841172
ID:
300841172

SRA Run Selector

8.

LK2(+/+)-iPSC

Organism:
Homo sapiens
Source name:
wild-type iPSCs
Platform:
GPL11154
Series:
GSE34061
Download data: BED, BW
Sample
Accession:
GSM841171
ID:
300841171

SRA Run Selector

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