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Items: 20

1.

Suppression of the antiviral response by an influenza "histone mimic"

(Submitter supplied) Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 target the transcription elongation PAF1 complex (hPAF1C). We demonstrate that binding of NS1 to hPAF1C results in suppression of hPAF1C-mediated transcriptional elongation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL10999 GPL11154
17 Samples
Download data: BED
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

Illumina Genome Analyzer IIx (Homo sapiens)

Platform
Accession:
GPL10999
ID:
100010999
4.

GRO-Seq 12h delta-PAF

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874649
ID:
300874649
5.

GRO-Seq 12h WT

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874648
ID:
300874648
6.

GRO-Seq 0h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874647
ID:
300874647
7.

si-CTRL-ui

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874642
ID:
300874642
8.

si-CHD1-flu

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874641
ID:
300874641
9.

si-hPAF1-flu

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874640
ID:
300874640
10.

si-CTRL-flu

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874639
ID:
300874639
11.

PAF1C 12h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874636
ID:
300874636
12.

PAF1C 0h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL11154
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874635
ID:
300874635
13.

RNA-Seq 12h (read 1/2)

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874645
ID:
300874645
14.

RNA-Seq 0h (read 1/2)

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874643
ID:
300874643
15.

NS1 012h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874638
ID:
300874638
16.

NS1 0h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874637
ID:
300874637
17.

RNAPII 12h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874634
ID:
300874634
18.

RNAPII 0h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874633
ID:
300874633
19.

K4me3 12h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874632
ID:
300874632
20.

K4me3 0h

Organism:
Homo sapiens
Source name:
A549 cells
Platform:
GPL10999
Series:
GSE35268 GSE35774
Download data: BED
Sample
Accession:
GSM874631
ID:
300874631
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Supplemental Content

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