GSE36185[Accession] - GEO DataSets - NCBI

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Items: 16

Select item 2000361851.

mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription

(Submitter supplied) We report a function of human mRNA decapping factors in control of transcription by RNA polymerase II. Decapping proteins Edc3, Dcp1a and Dcp2 and the termination factor TTF2 co-immunoprecipitate with Xrn2, the nuclear 5'-3' exonuclease torpedo that facilitates transcription termination at the 3' ends of genes. Dcp1a, Xrn2 and TTF2 localize near transcription start sites (TSSs) by ChIP-Seq. At genes with 5' peaks of paused pol II, knockdown of decapping or termination factors, Xrn2 and TTF2, shifted polymerase away from the TSS toward upstream and downstream distal positions. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL10999 GPL11154
13 Samples

Download data: WIG

Series

Accession:: GSE36185

ID:: 200036185

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000111542.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10400 Series
180082 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 1000109993.

Illumina Genome Analyzer IIx (Homo sapiens)

Organism:: Homo sapiens

1096 Series
9927 Samples

Platform

Accession:: GPL10999

ID:: 100010999

Select item 3008912334.

TTF2 ChIP-Seq (antibody 1)

Organism:: Homo sapiens

Source name:: HeLa, TTF2 ChIP

Platform:: GPL11154
Series:: GSE36185

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Sample

Accession:: GSM891233

ID:: 300891233

SRA Run Selector

Select item 3008912445.

RNA pol II ChIP-Seq Dcp2 shRNA

Organism:: Homo sapiens

Source name:: HEK293, Dcp2 shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891244

ID:: 300891244

SRA Run Selector

Select item 3008912436.

RNA pol II ChIP-Seq Dcp1a shRNA

Organism:: Homo sapiens

Source name:: HEK293, Dcp1a shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891243

ID:: 300891243

SRA Run Selector

Select item 3008912427.

RNA pol II ChIP-Seq Edc3 shRNA

Organism:: Homo sapiens

Source name:: HEK293, Edc3 shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891242

ID:: 300891242

SRA Run Selector

Select item 3008912418.

RNA pol II ChIP-Seq TTF2+Xrn2 shRNA

Organism:: Homo sapiens

Source name:: HEK293, TTF2+Xrn2 shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891241

ID:: 300891241

SRA Run Selector

Select item 3008912409.

RNA pol II ChIP-Seq Xrn2 shRNA

Organism:: Homo sapiens

Source name:: HEK293, Xrn2 shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891240

ID:: 300891240

SRA Run Selector

Select item 30089123910.

RNA pol II ChIP-Seq TTF2 shRNA

Organism:: Homo sapiens

Source name:: HEK293, TTF2 shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891239

ID:: 300891239

SRA Run Selector

Select item 30089123811.

RNA pol II ChIP-Seq scr shRNA control

Organism:: Homo sapiens

Source name:: HEK293, scrambled shRNA, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891238

ID:: 300891238

SRA Run Selector

Select item 30089123712.

RNA pol II ChIP-Seq parent control

Organism:: Homo sapiens

Source name:: HEK293, RNA pol II ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891237

ID:: 300891237

SRA Run Selector

Select item 30089123613.

Organism:: Homo sapiens

Source name:: HeLa, Dcp1a ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891236

ID:: 300891236

SRA Run Selector

Select item 30089123514.

Organism:: Homo sapiens

Source name:: HeLa, Xrn2 ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891235

ID:: 300891235

SRA Run Selector

Select item 30089123415.

TTF2 ChIP-Seq (antibody 2)

Organism:: Homo sapiens

Source name:: HeLa, TTF2 ChIP

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891234

ID:: 300891234

SRA Run Selector

Select item 30089123216.

Hela input chromatin

Organism:: Homo sapiens

Source name:: HeLa, input

Platform:: GPL10999
Series:: GSE36185

Download data: WIG

Sample

Accession:: GSM891232

ID:: 300891232

SRA Run Selector

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