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Items: 8

1.

Hes6 expression is controlled by c-Myc and the AR to promote E2F1 activity and poor outcome in castrate-resistant prostate cancer (E2F1 ChIP-seq)

(Submitter supplied) Hes6 is a transcription co-factor that is associated with stem cell characteristics in neural tissue, but its role in cancer remains uncertain. Here we show that Hes6 is controlled by c-Myc and the AR and can drive castration resistance in xenografts of the androgen-dependent LNCaP prostate cancer cell line model. Hes6 activates a cell cycle enhancing transcriptional network that maintains tumour growth in the absence of circulating androgen but with maintained nuclear AR. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
6 Samples
Download data: WIG
Series
Accession:
GSE36614
ID:
200036614
2.

Illumina Genome Analyzer (Homo sapiens)

Platform
Accession:
GPL9052
ID:
100009052
3.

4-LNCaP-Hes6-Bic-E2F1-ChIP

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897554
ID:
300897554
4.

3-LNCaP-Hes6-Veh-E2F1-ChIP

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897553
ID:
300897553
5.

2-LNCaP-EV-Bic-E2F1-ChIP

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897552
ID:
300897552
6.

1-LNCaP-EV-Veh-E2F1-ChIP

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897551
ID:
300897551
7.

input36-EV-Full (E2F1 )

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897550
ID:
300897550
8.

input1-Hes6-Castrated (E2F1 )

Organism:
Homo sapiens
Source name:
LNCaP cells
Platform:
GPL9052
Series:
GSE36526 GSE36614
Download data: WIG
Sample
Accession:
GSM897549
ID:
300897549
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Supplemental Content

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