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Items: 10

1.

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits

(Submitter supplied) The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell lineage-specific transcription factors. Here we report that repression of a single RNA binding protein PTB, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL9115 GPL11154
7 Samples
Download data: BED
Series
Accession:
GSE42701
ID:
200042701

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

Illumina Genome Analyzer II (Homo sapiens)

Organism:
Homo sapiens
753 Series
6113 Samples
Download data
Platform
Accession:
GPL9115
ID:
100009115

4.

Hela_PTB_CLIP_2nd

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL11154
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048186
ID:
301048186

SRA Run Selector

5.

Hela_PTB_3end_RNAseq_knockdown_0h and 4h

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048192
ID:
301048192

SRA Run Selector

6.

Hela_PTB_3end_RNAseq_control_0h and 4h

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048191
ID:
301048191

SRA Run Selector

7.

Hela_PTB_RNAseq_knockdown

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048190
ID:
301048190

SRA Run Selector

8.

Hela_PTB_RNAseq_control

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048189
ID:
301048189

SRA Run Selector

9.

Hela_AGO2_CLIP_ptb_knockdown

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048188
ID:
301048188

SRA Run Selector

10.

Hela_AGO2_CLIP_control

Organism:
Homo sapiens
Source name:
Hela cells
Platform:
GPL9115
Series:
GSE42701
Download data: BED
Sample
Accession:
GSM1048187
ID:
301048187

SRA Run Selector

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db=gds|term=GSE42701[Accession]|query=1|qty=2|blobid=MCID_66432f22ec958f7d1002470a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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