GSE43526[Accession] - GEO DataSets - NCBI

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Items: 17

Select item 2000435261.

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]

(Submitter supplied) Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomerases selectively inhibit long genes (>100kb), with little effect on all other gene expression. Using ChIPseq against RNA Polymerase II (Pol2) we show that the Top1 inhibitor topotecan blocks transcriptional elongation of long genes specifically. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154
14 Samples

Download data: TXT

Series

Accession:: GSE43526

ID:: 200043526

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000131122.

Illumina HiSeq 2000 (Mus musculus)

Organism:: Mus musculus

8229 Series
187279 Samples

Platform

Accession:: GPL13112

ID:: 100013112

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10400 Series
180082 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3011799284.

Topotecan_RNAseq [human]

Organism:: Homo sapiens

Source name:: iPSCs were differentiated into forebrain cortical neurons and treated with 10µM topotecan for 6 days.

Platform:: GPL11154
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1179928

ID:: 301179928

SRA Run Selector

Select item 3011799275.

Vehicle_RNAseq [human]

Organism:: Homo sapiens

Source name:: iPSCs were differentiated into forebrain cortical neurons and treated with vehicle for 6 days.

Platform:: GPL11154
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1179927

ID:: 301179927

SRA Run Selector

Select item 3010649446.

Topotecan_Chipseq [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064944

ID:: 301064944

SRA Run Selector

Select item 3010649437.

Vehicle_Chipseq [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064943

ID:: 301064943

SRA Run Selector

Select item 3010649428.

Topotecan_RNAseq_rep5 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064942

ID:: 301064942

SRA Run Selector

Select item 3010649419.

Topotecan_RNAseq_rep4 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064941

ID:: 301064941

SRA Run Selector

Select item 30106494010.

Topotecan_RNAseq_rep3 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064940

ID:: 301064940

SRA Run Selector

Select item 30106493911.

Topotecan_RNAseq_rep2 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064939

ID:: 301064939

SRA Run Selector

Select item 30106493812.

Topotecan_RNAseq_rep1 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064938

ID:: 301064938

SRA Run Selector

Select item 30106493713.

Vehicle_RNAseq_rep5 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064937

ID:: 301064937

SRA Run Selector

Select item 30106493614.

Vehicle_RNAseq_rep4 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064936

ID:: 301064936

SRA Run Selector

Select item 30106493515.

Vehicle_RNAseq_rep3 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064935

ID:: 301064935

SRA Run Selector

Select item 30106493416.

Vehicle_RNAseq_rep2 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064934

ID:: 301064934

SRA Run Selector

Select item 30106493317.

Vehicle_RNAseq_rep1 [mouse]

Organism:: Mus musculus

Source name:: cultured cortical neurons

Platform:: GPL13112
Series:: GSE43526 GSE43900

Download data: TXT

Sample

Accession:: GSM1064933

ID:: 301064933

SRA Run Selector

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