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Items: 13

1.

Mechanisms of Ikaros Tumor Suppression with HDAC1 through distinct histone markers in Pre-B ALL Leukemia

(Submitter supplied) Ikaros functions as a master regulator of lymphocyte differentiation and a tumor suppressor. Ikaros binds DNA and regulates gene expression by chromatin remodeling. Mechanisms of Ikaros-mediated tumor suppression are unknown. Here we examined genome-wide occupancy of Ikaros and histone deacetylase 1 (HDAC1) and Histone midificaition markers in human leukemia, and found that the Ikaros and HDAC1 showed similar binding partern and HDAC1–DNA interactions are associated with the presence of bivalent chromatin, and the recruitment of HDAC1 by Ikaros is associated with bivalent chromatin at Ikaros target genes.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL9115
10 Samples
Download data: COD
Series
Accession:
GSE44217
ID:
200044217

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

Illumina Genome Analyzer II (Homo sapiens)

Organism:
Homo sapiens
753 Series
6113 Samples
Download data
Platform
Accession:
GPL9115
ID:
100009115

4.

H3K4me3_suppl_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL11154
Series:
GSE44217 GSE44218
Download data
Sample
Accession:
GSM2521639
ID:
302521639

SRA Run Selector

5.

H3K27me3_suppl_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL11154
Series:
GSE44217 GSE44218
Download data
Sample
Accession:
GSM2521638
ID:
302521638

SRA Run Selector

6.

input_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data
Sample
Accession:
GSM1080938
ID:
301080938

SRA Run Selector

7.

H3K36me3_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080937
ID:
301080937

SRA Run Selector

8.

H3K27me3_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080935
ID:
301080935

SRA Run Selector

9.

H3K9ac_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080934
ID:
301080934

SRA Run Selector

10.

H3K9me3_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080933
ID:
301080933

SRA Run Selector

11.

Ikaros_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL9115
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080931
ID:
301080931

SRA Run Selector

12.

H3K4me3_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL11154
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080936
ID:
301080936

SRA Run Selector

13.

HDAC1_ChIP-seq

Organism:
Homo sapiens
Source name:
Nalm6 ALL leukemia cells
Platform:
GPL11154
Series:
GSE44217 GSE44218
Download data: COD
Sample
Accession:
GSM1080932
ID:
301080932

SRA Run Selector

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