GSE45982[Accession] - GEO DataSets - NCBI

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Select item 2000459821.

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

(Submitter supplied) The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently suppress GC B-cell differentiation. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154 GPL10999
61 Samples

Download data: BED, TXT, WIG

Series

Accession:: GSE45982

ID:: 200045982

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000131122.

Illumina HiSeq 2000 (Mus musculus)

Organism:: Mus musculus

8229 Series
187279 Samples

Platform

Accession:: GPL13112

ID:: 100013112

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10400 Series
180082 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 1000109994.

Illumina Genome Analyzer IIx (Homo sapiens)

Organism:: Homo sapiens

1096 Series
9927 Samples

Platform

Accession:: GPL10999

ID:: 100010999

Select item 3011293645.

Organism:: Homo sapiens

Source name:: Pfeiffer cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129364

ID:: 301129364

SRA Run Selector

Select item 3011293636.

Organism:: Homo sapiens

Source name:: WSUDLCL2 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129363

ID:: 301129363

SRA Run Selector

Select item 3011293627.

Organism:: Homo sapiens

Source name:: SUDHL6 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129362

ID:: 301129362

SRA Run Selector

Select item 3011293618.

Organism:: Homo sapiens

Source name:: OCI-Ly1 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129361

ID:: 301129361

SRA Run Selector

Select item 3011293609.

Organism:: Homo sapiens

Source name:: SUDHL5 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129360

ID:: 301129360

SRA Run Selector

Select item 30112935910.

Organism:: Homo sapiens

Source name:: Farage cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129359

ID:: 301129359

SRA Run Selector

Select item 30112935811.

Organism:: Homo sapiens

Source name:: OCI-Ly7 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: WIG

Sample

Accession:: GSM1129358

ID:: 301129358

SRA Run Selector

Select item 30112934712.

Organism:: Homo sapiens

Source name:: Tonsillar Germinal Center B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129347

ID:: 301129347

SRA Run Selector

Select item 30112934613.

Organism:: Homo sapiens

Source name:: Tonsillar Germinal Center B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129346

ID:: 301129346

SRA Run Selector

Select item 30112934514.

Organism:: Homo sapiens

Source name:: Tonsillar Germinal Center B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129345

ID:: 301129345

SRA Run Selector

Select item 30112934415.

Organism:: Homo sapiens

Source name:: Tonsillar Germinal Center B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129344

ID:: 301129344

SRA Run Selector

Select item 30112934316.

Organism:: Homo sapiens

Source name:: Tonsillar Naïve B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129343

ID:: 301129343

SRA Run Selector

Select item 30112934217.

Organism:: Homo sapiens

Source name:: Tonsillar Naïve B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129342

ID:: 301129342

SRA Run Selector

Select item 30112934118.

Organism:: Homo sapiens

Source name:: Tonsillar Naïve B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129341

ID:: 301129341

SRA Run Selector

Select item 30112934019.

Organism:: Homo sapiens

Source name:: Tonsillar Naïve B cells

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129340

ID:: 301129340

SRA Run Selector

Select item 30112933320.

WSUDLCL2 scrambled

Organism:: Homo sapiens

Source name:: WSUDLCL2 cell line

Platform:: GPL11154
Series:: GSE45982

Download data: TXT

Sample

Accession:: GSM1129333

ID:: 301129333

SRA Run Selector

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