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Items: 1 to 20 of 36

1.

Discovery and Characterization of Super-Enhancer Associated Dependencies in Diffuse Large B-Cell Lymphoma

(Submitter supplied) Diffuse Large B-Cell Lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of BET bromodomain proteins in DLBCL, using integrative chemical genetics and functional epigenomics. We observe highly asymmetric loading of BRD4 at enhancers, with approximately 33% of all BRD4 localizing to enhancers at 1.6% of occupied genes. These super-enhancers prove particularly sensitive to bromodomain inhibition, explaining the selective effect of BET inhibitors on oncogenic and lineage-specific transcriptional circuits. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
34 Samples
Download data: WIG
Series
Accession:
GSE46663
ID:
200046663

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

P448_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254217
ID:
301254217

SRA Run Selector

4.

P448_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254216
ID:
301254216

SRA Run Selector

5.

P397_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254215
ID:
301254215

SRA Run Selector

6.

P397_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254214
ID:
301254214

SRA Run Selector

7.

P286_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254213
ID:
301254213

SRA Run Selector

8.

P286_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254212
ID:
301254212

SRA Run Selector

9.

P265_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254211
ID:
301254211

SRA Run Selector

10.

P265_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254210
ID:
301254210

SRA Run Selector

11.

P14A_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254209
ID:
301254209

SRA Run Selector

12.

P14A_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254208
ID:
301254208

SRA Run Selector

13.

P107A_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254207
ID:
301254207

SRA Run Selector

14.

P107A_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254206
ID:
301254206

SRA Run Selector

15.

TOLEDO_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254203
ID:
301254203

SRA Run Selector

16.

TOLEDO_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254202
ID:
301254202

SRA Run Selector

17.

LY4_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254201
ID:
301254201

SRA Run Selector

18.

LY4_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254200
ID:
301254200

SRA Run Selector

19.

LY3_WCE

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254199
ID:
301254199

SRA Run Selector

20.

LY3_H3K27AC

Organism:
Homo sapiens
Source name:
Diffuse Large B-Cell Lymphoma
Platform:
GPL11154
Series:
GSE46663
Download data: WIG
Sample
Accession:
GSM1254198
ID:
301254198

SRA Run Selector

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