GSE46837[Accession] - GEO DataSets - NCBI

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Items: 13

Select item 2000468371.

SOX2 and p63 occupancy in human squamous carcinoma cell lines and embryonic stem cells.

(Submitter supplied) SOX2 is a transcription factor essential for pluripotent stem cells, and development and maintenance of squamous epithelium. We previously reported SOX2 an oncogene subject to highly recurrent genomic amplification in squamous cell carcinomas (SCCs). Here we demonstrate in SCCs that SOX2 interacts with another master squamous transcription factor p63, and through ChIP-seq show that genomic occupancy of SOX2 overlaps with that of p63 at a large number of loci and that they cooperatively regulate gene expression including ETV4, which we find essential for SOX2-amplified SCC cell survival. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data: BED

Series

Accession:: GSE46837

ID:: 200046837

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000111542.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10400 Series
180082 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3011390413.

Organism:: Homo sapiens

Source name:: H9_SOX2_AF2018

Platform:: GPL11154
Series:: GSE46837

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Sample

Accession:: GSM1139041

ID:: 301139041

SRA Run Selector

Select item 3011390404.

Organism:: Homo sapiens

Source name:: H9_input

Platform:: GPL11154
Series:: GSE46837

Sample

Accession:: GSM1139040

ID:: 301139040

SRA Run Selector

Select item 3011390395.

Organism:: Homo sapiens

Source name:: HCC95_p63_4A4

Platform:: GPL11154
Series:: GSE46837

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Sample

Accession:: GSM1139039

ID:: 301139039

SRA Run Selector

Select item 3011390386.

HCC95_SOX2_AF2018

Organism:: Homo sapiens

Source name:: HCC95_SOX2_AF2018

Platform:: GPL11154
Series:: GSE46837

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Sample

Accession:: GSM1139038

ID:: 301139038

SRA Run Selector

Select item 3011390377.

Organism:: Homo sapiens

Source name:: HCC95_input

Platform:: GPL11154
Series:: GSE46837

Sample

Accession:: GSM1139037

ID:: 301139037

SRA Run Selector

Select item 3011390368.

Organism:: Homo sapiens

Source name:: TT_p63_4A4

Platform:: GPL11154
Series:: GSE46837

Download data: BED

Sample

Accession:: GSM1139036

ID:: 301139036

SRA Run Selector

Select item 3011390359.

Organism:: Homo sapiens

Source name:: TT_SOX2_AF2018

Platform:: GPL11154
Series:: GSE46837

Download data: BED

Sample

Accession:: GSM1139035

ID:: 301139035

SRA Run Selector

Select item 30113903410.

Organism:: Homo sapiens

Source name:: TT_input

Platform:: GPL11154
Series:: GSE46837

Sample

Accession:: GSM1139034

ID:: 301139034

SRA Run Selector

Select item 30113903311.

Organism:: Homo sapiens

Source name:: KYSE70_p63_4A4

Platform:: GPL11154
Series:: GSE46837

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Sample

Accession:: GSM1139033

ID:: 301139033

SRA Run Selector

Select item 30113903212.

KYSE70_SOX2_AF2018

Organism:: Homo sapiens

Source name:: KYSE70_SOX2_AF2018

Platform:: GPL11154
Series:: GSE46837

Download data: BED

Sample

Accession:: GSM1139032

ID:: 301139032

SRA Run Selector

Select item 30113903113.

Organism:: Homo sapiens

Source name:: KYSE70_input

Platform:: GPL11154
Series:: GSE46837

Sample

Accession:: GSM1139031

ID:: 301139031

SRA Run Selector

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