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Items: 8

1.

Differential gene expression by suppression of either SOX2 or TP63 in KYSE70 human esophageal squamous carcinoma cell line.

(Submitter supplied) SOX2 is a transcription factor essential for pluripotent stem cells, and development and maintenance of squamous epithelium. We previously reported SOX2 an oncogene subject to highly recurrent genomic amplification in squamous cell carcinomas (SCCs)1. Here we demonstrate in SCCs that SOX2 interacts with another master squamous transcription factor p63, and through ChIP-seq show that genomic occupancy of SOX2 overlaps with that of p63 at a large number of loci and that they cooperatively regulate gene expression including ETV4, which we find essential for SOX2-amplified SCC cell survival. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE47058
ID:
200047058

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

KYSE70 shTP63(1) Day 4

Organism:
Homo sapiens
Source name:
KYSE70_shTP63_Day 4
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143928
ID:
301143928

SRA Run Selector

4.

KYSE70 shTP63(2) Day 4

Organism:
Homo sapiens
Source name:
KYSE70_shTP63_Day 4
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143927
ID:
301143927

SRA Run Selector

5.

KYSE70 shTP63(2) Day 0

Organism:
Homo sapiens
Source name:
KYSE70_shTP63_Day 0
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143926
ID:
301143926

SRA Run Selector

6.

KYSE70 shSOX2(1) Day 4

Organism:
Homo sapiens
Source name:
KYSE70_shSOX2_Day 4
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143925
ID:
301143925

SRA Run Selector

7.

KYSE70 shSOX2(2) Day 4

Organism:
Homo sapiens
Source name:
KYSE70_shSOX2_Day 4
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143924
ID:
301143924

SRA Run Selector

8.

KYSE70 shSOX2(2) Day 0

Organism:
Homo sapiens
Source name:
KYSE70_shSOX2_Day 0
Platform:
GPL11154
Series:
GSE47058
Download data
Sample
Accession:
GSM1143923
ID:
301143923

SRA Run Selector

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