GSE47114[Accession] - GEO DataSets - NCBI

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Items: 9

Select item 2000471141.

RNA-Guided Human Gene Activation by Cas9/CRISPR-Based Engineered Transcription Factors

(Submitter supplied) Synthetic transcription factors can be applied in many areas of biotechnology, medicine, and basic research. In contrast to current methods based on engineering new DNA-binding proteins, we show that Cas9 fused to a transcriptional activation domain can be targeted by combinations of guide RNA molecules to induce the expression of endogenous human genes. This simple approach for targeted gene activation circumvents the need for engineering new proteins and will enable widespread synthetic gene regulation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
7 Samples

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Series

Accession:: GSE47114

ID:: 200047114

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000111542.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10400 Series
180082 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3011451423.

HBG CRISPRs, Rep 3

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with Cas9 and HBG1/2 guide RNA expressing plasmids

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145142

ID:: 301145142

SRA Run Selector

Select item 3011451414.

HBG CRISPRs, Rep 2

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with Cas9 and HBG1/2 guide RNA expressing plasmids

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145141

ID:: 301145141

SRA Run Selector

Select item 3011451405.

HBG CRISPRs, Rep 1

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with Cas9 and HBG1/2 guide RNA expressing plasmids

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145140

ID:: 301145140

SRA Run Selector

Select item 3011451396.

IL1RN CRISPRs, Rep 2

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with Cas9 and IL1RN guide RNA expressing plasmids

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145139

ID:: 301145139

SRA Run Selector

Select item 3011451387.

IL1RN CRISPRs, Rep 1

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with Cas9 and IL1RN guide RNA expressing plasmids

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145138

ID:: 301145138

SRA Run Selector

Select item 3011451378.

Control treated, Rep 2

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with empty guide-RNA expressing vector

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145137

ID:: 301145137

SRA Run Selector

Select item 3011451369.

Control treated, Rep 1

Organism:: Homo sapiens

Source name:: HEK293T cells transiently transfected with empty guide-RNA expressing vector

Platform:: GPL11154
Series:: GSE47114

Sample

Accession:: GSM1145136

ID:: 301145136

SRA Run Selector

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