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Items: 11

1.

Genome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin

(Submitter supplied) The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a “cleavable complex”. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment affected transcription initiation, elongation, termination, splicing and enhancer activity. Following removal of camptothecin, transcription spread as a wave from the 5’-end of genes with no recovery of transcription apparent from RNA polymerases stalled in the body of genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
9 Samples
Download data: TXT
Series
Accession:
GSE48678
ID:
200048678

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

csbCPT30m1

Organism:
Homo sapiens
Source name:
Cockayne syndrome group B fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183342
ID:
301183342

SRA Run Selector

4.

csbCPT15m1

Organism:
Homo sapiens
Source name:
Cockayne syndrome group B fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183341
ID:
301183341

SRA Run Selector

5.

csbCPT0m1

Organism:
Homo sapiens
Source name:
Cockayne syndrome group B fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183340
ID:
301183340

SRA Run Selector

6.

csb0h1

Organism:
Homo sapiens
Source name:
Cockayne syndrome group B fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183339
ID:
301183339

SRA Run Selector

7.

nfCPT30m1

Organism:
Homo sapiens
Source name:
Foreskin fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183338
ID:
301183338

SRA Run Selector

8.

nfCPT15m1

Organism:
Homo sapiens
Source name:
Foreskin fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183337
ID:
301183337

SRA Run Selector

9.

nfCPT0m1

Organism:
Homo sapiens
Source name:
Foreskin fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183336
ID:
301183336

SRA Run Selector

10.

nf0h3b

Organism:
Homo sapiens
Source name:
Foreskin fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183335
ID:
301183335

SRA Run Selector

11.

nf0h3a

Organism:
Homo sapiens
Source name:
Foreskin fibroblasts
Platform:
GPL11154
Series:
GSE48678
Download data: TXT
Sample
Accession:
GSM1183334
ID:
301183334

SRA Run Selector

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db=gds|term=GSE48678[Accession]|query=1|qty=2|blobid=MCID_6643e09dec958f7d1015e230|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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