GSE55921[Accession] - GEO DataSets - NCBI

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Select item 2000559211.

Bromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [ChIP-seq]

(Submitter supplied) The estrogen receptor-α (ERα) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptional mechanisms may uncover novel therapeutic targets for ERα-dependent cancers. Here we show for the first time that BRD4 regulates ERα−induced gene expression by affecting elongation-associated phosphorylation of RNA Polymerase II (RNAPII P-Ser2) and histone H2B monoubiquitination (H2Bub1). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
26 Samples

Download data: WIG

Series

Accession:: GSE55921

ID:: 200055921

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

11829 Series
336719 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3013485403.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348540

ID:: 301348540

SRA Run Selector

Select item 3013485394.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348539

ID:: 301348539

SRA Run Selector

Select item 3013485385.

H2Bub1 JQ1 E2 rep3

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348538

ID:: 301348538

SRA Run Selector

Select item 3013485376.

H2Bub1 JQ1 E2 rep2

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348537

ID:: 301348537

SRA Run Selector

Select item 3013485367.

H2Bub1 JQ1 E2 rep1

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348536

ID:: 301348536

SRA Run Selector

Select item 3013485358.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348535

ID:: 301348535

SRA Run Selector

Select item 3013485349.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348534

ID:: 301348534

SRA Run Selector

Select item 30134853310.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348533

ID:: 301348533

SRA Run Selector

Select item 30134853211.

H2Bub1 JQ1 Veh rep3

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348532

ID:: 301348532

SRA Run Selector

Select item 30134853112.

H2Bub1 JQ1 Veh rep2

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348531

ID:: 301348531

SRA Run Selector

Select item 30134853013.

H2Bub1 JQ1 Veh rep1

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348530

ID:: 301348530

SRA Run Selector

Select item 30134852914.

H2Bub1 Veh rep3

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348529

ID:: 301348529

SRA Run Selector

Select item 30134852815.

H2Bub1 Veh rep2

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348528

ID:: 301348528

SRA Run Selector

Select item 30134852716.

H2Bub1 Veh rep1

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348527

ID:: 301348527

SRA Run Selector

Select item 30134852617.

ERα JQ1 E2 rep3

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348526

ID:: 301348526

SRA Run Selector

Select item 30134852518.

ERα JQ1 E2 rep2

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348525

ID:: 301348525

SRA Run Selector

Select item 30134852419.

ERα JQ1 E2 rep1

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348524

ID:: 301348524

SRA Run Selector

Select item 30134852320.

Organism:: Homo sapiens

Source name:: MCF7 breast cancer cells

Platform:: GPL16791
Series:: GSE55921 GSE55923

Sample

Accession:: GSM1348523

ID:: 301348523

SRA Run Selector

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