GSE59657[Accession] - GEO DataSets - NCBI

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Select item 2000596571.

An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element

(Submitter supplied) In many cancers, critical oncogenes are driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive H3K27 acetylation. We found that in T-cell acute lymphoblastic leukemia (T-ALL), somatic heterozygous mutations introduce MYB binding motifs in a precise noncoding site, which nucleate a super-enhancer upstream of the TAL1 oncogene. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154 GPL9115
20 Samples

Download data: WIG

Series

Accession:: GSE59657

ID:: 200059657

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

11814 Series
336528 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10406 Series
180377 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 1000091154.

Illumina Genome Analyzer II (Homo sapiens)

Organism:: Homo sapiens

753 Series
6113 Samples

Platform

Accession:: GPL9115

ID:: 100009115

Select item 3014420035.

H3K27Ac ChIP RPMI-8402_ChipSeq 11132012_64WVDAAXX_4

Organism:: Homo sapiens

Source name:: T-ALL cell line

Platform:: GPL9115
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1442003

ID:: 301442003

SRA Run Selector

Select item 3014420026.

TAL1 ChIP-seq in HSPC rep2 04102009_3139VAAXX_B1

Organism:: Homo sapiens

Source name:: Hematopoietic Stem & Progenitor Cells

Platform:: GPL9115
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1442002

ID:: 301442002

SRA Run Selector

Select item 3014420017.

TAL1 ChIP-seq in HSPC rep1 05062009_427E3AAXX_B3

Organism:: Homo sapiens

Source name:: Hematopoietic Stem & Progenitor Cells

Platform:: GPL9115
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1442001

ID:: 301442001

SRA Run Selector

Select item 3015196428.

ChIP:H3K27ac_ab4729_Jurkat3_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519642

ID:: 301519642

SRA Run Selector

Select item 3015196419.

ChIP:MYB_ab45150_Jurkat3_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519641

ID:: 301519641

SRA Run Selector

Select item 30151964010.

Input for ChIP:Jurkat3_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519640

ID:: 301519640

SRA Run Selector

Select item 30151963911.

ChIP:MYB_ab45150_Jurkat4_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519639

ID:: 301519639

SRA Run Selector

Select item 30151963812.

ChIP:H3K27ac_ab4729_Jurkat1_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519638

ID:: 301519638

SRA Run Selector

Select item 30151963713.

Input for ChIP:Jurkat1_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519637

ID:: 301519637

SRA Run Selector

Select item 30151963614.

Input for ChIP:Jurkat4_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519636

ID:: 301519636

SRA Run Selector

Select item 30151963515.

ChIP:MYB_ab45150_Jurkat1_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519635

ID:: 301519635

SRA Run Selector

Select item 30151963416.

ChIP:H3K27ac_ab4729_Jurkat4_091914 [lab: Look-DFCI]

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL16791
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519634

ID:: 301519634

SRA Run Selector

Select item 30151964617.

ChIP:TAL1_sc12984_MOLT3_062714

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL11154
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519646

ID:: 301519646

SRA Run Selector

Select item 30151964518.

Input for ChIP:MOLT3_062714

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL11154
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519645

ID:: 301519645

SRA Run Selector

Select item 30151964419.

ChIP:H3K27ac_ab4729_MOLT3_062714

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL11154
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519644

ID:: 301519644

SRA Run Selector

Select item 30151964320.

ChIP:vMYB_ab45150_MOLT3_062714

Organism:: Homo sapiens

Source name:: T-ALL

Platform:: GPL11154
Series:: GSE59657

Download data: WIG

Sample

Accession:: GSM1519643

ID:: 301519643

SRA Run Selector

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