GSE62171[Accession] - GEO DataSets - NCBI

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Select item 2000621711.

RNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II

(Submitter supplied) Release of promoter-proximal paused RNA polymerase II (Pol II) during early elongation is a critical step in transcriptional regulation in metazoan cells. Paused Pol II release is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation of DRB sensitivity-inducing factor, negative elongation factor, and C-terminal domain (CTD) serine-2 of Pol II. We found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
32 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE62171

ID:: 200062171

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

11830 Series
336732 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10410 Series
180450 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3019058274.

Organism:: Homo sapiens

Source name:: THP1, pLKO.1-PAF1 shRNA #1

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1905827

ID:: 301905827

SRA Run Selector

Select item 3019058265.

Organism:: Homo sapiens

Source name:: THP1, pLKO.1 control

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1905826

ID:: 301905826

SRA Run Selector

Select item 3015209196.

Organism:: Homo sapiens

Source name:: THP1_PAF1KD_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520919

ID:: 301520919

SRA Run Selector

Select item 3015209187.

Organism:: Homo sapiens

Source name:: THP1_vector-control_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520918

ID:: 301520918

SRA Run Selector

Select item 3015209178.

Organism:: Homo sapiens

Source name:: THP1_PAF1KD_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520917

ID:: 301520917

SRA Run Selector

Select item 3015209169.

Organism:: Homo sapiens

Source name:: THP1_vector-control_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520916

ID:: 301520916

SRA Run Selector

Select item 30152091510.

Organism:: Homo sapiens

Source name:: THP1_Flavopiridol_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520915

ID:: 301520915

SRA Run Selector

Select item 30152091411.

Organism:: Homo sapiens

Source name:: THP1_DMSO_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520914

ID:: 301520914

SRA Run Selector

Select item 30152091312.

Organism:: Homo sapiens

Source name:: THP1_Flavopiridol_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520913

ID:: 301520913

SRA Run Selector

Select item 30152091213.

Organism:: Homo sapiens

Source name:: THP1_DMSO_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520912

ID:: 301520912

SRA Run Selector

Select item 30152091114.

Organism:: Homo sapiens

Source name:: THP1_WT_input

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520911

ID:: 301520911

SRA Run Selector

Select item 30152091015.

Organism:: Homo sapiens

Source name:: THP1_WT_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520910

ID:: 301520910

SRA Run Selector

Select item 30152090916.

Organism:: Homo sapiens

Source name:: THP1_WT_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520909

ID:: 301520909

SRA Run Selector

Select item 30152090817.

Organism:: Homo sapiens

Source name:: THP1_WT_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520908

ID:: 301520908

SRA Run Selector

Select item 30152090718.

Organism:: Homo sapiens

Source name:: THP1_WT_ChIP-seq

Platform:: GPL11154
Series:: GSE62171

Download data: BEDGRAPH

Sample

Accession:: GSM1520907

ID:: 301520907

SRA Run Selector

Select item 30152090619.

PAF1KD-2-THP1 RNAseq

Organism:: Homo sapiens

Source name:: THP1_PAF1KD_RNA-seq

Platform:: GPL11154
Series:: GSE62171

Download data: TXT

Sample

Accession:: GSM1520906

ID:: 301520906

SRA Run Selector

Select item 30152090520.

PAF1KD-1-THP1 RNAseq

Organism:: Homo sapiens

Source name:: THP1_PAF1KD_RNA-seq

Platform:: GPL11154
Series:: GSE62171

Download data: TXT

Sample

Accession:: GSM1520905

ID:: 301520905

SRA Run Selector

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