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Items: 1 to 20 of 110

1.

Transcriptional plasticity promotes primary and acquired resistance to BET bromodomain inhibition

(Submitter supplied) Following the discovery of BRD4 as a non-oncogene addiction target in acute myeloid leukemia (AML), BET inhibitors are being explored as promising therapeutic avenue in numerous cancers. While clinical trials have reported single-agent activity in advanced hematologic malignancies, mechanisms determining the response to BET inhibition remain poorly understood. To identify factors involved in primary and acquired BET resistance in leukemia, we performed a chromatin-focused shRNAmir screen in a sensitive MLL/AF9; NrasG12D‑driven AML model, and investigated dynamic transcriptional profiles in sensitive and resistant murine and human leukemias. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
6 related Platforms
103 Samples
Download data: BED, BW, GTF, TSV
Series
Accession:
GSE63782
ID:
200063782

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 1500 (Mus musculus)

Organism:
Mus musculus
584 Series
10884 Samples
Download data
Platform
Accession:
GPL18480
ID:
100018480

3.

Illumina HiSeq 1500 (Homo sapiens)

Organism:
Homo sapiens
383 Series
6902 Samples
Download data
Platform
Accession:
GPL18460
ID:
100018460

4.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
10744 Series
292828 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

5.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
11813 Series
336528 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

6.

Illumina HiSeq 2000 (Mus musculus)

Organism:
Mus musculus
8231 Series
187288 Samples
Download data
Platform
Accession:
GPL13112
ID:
100013112

7.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10403 Series
180361 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

8.

Molm13_Input

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL16791
Series:
GSE63782
Download data: BW
Sample
Accession:
GSM1652921
ID:
301652921

SRA Run Selector

9.

Molm13_H3K27ac

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL16791
Series:
GSE63782
Download data: BW
Sample
Accession:
GSM1652920
ID:
301652920

SRA Run Selector

10.

K562_Input

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL16791
Series:
GSE63782
Download data: BW
Sample
Accession:
GSM1652919
ID:
301652919

SRA Run Selector

11.

K562_H3K27ac

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL16791
Series:
GSE63782
Download data: BW
Sample
Accession:
GSM1652918
ID:
301652918

SRA Run Selector

12.

MOLM-13 BRD4.1817

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557123
ID:
301557123

SRA Run Selector

13.

MOLM-13 BRD3.3235

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557122
ID:
301557122

SRA Run Selector

14.

MOLM-13 BRD2.1638

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557121
ID:
301557121

SRA Run Selector

15.

MOLM-13 Ren.713

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557120
ID:
301557120

SRA Run Selector

16.

K-562 BRD4.1817

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557119
ID:
301557119

SRA Run Selector

17.

K-562 BRD3.3235

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557118
ID:
301557118

SRA Run Selector

18.

K-562 BRD2.1638

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557117
ID:
301557117

SRA Run Selector

19.

K-562 Ren.713

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557116
ID:
301557116

SRA Run Selector

20.

SU-8686 24h JQ1 200 nM

Organism:
Homo sapiens
Source name:
Cell line
Platform:
GPL18460
Series:
GSE63782
Download data
Sample
Accession:
GSM1557115
ID:
301557115

SRA Run Selector

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