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Items: 8

1.

BRD4 loading at the transcription start site mediates pause-release and underlies the disproportionate transcriptional response to BET bromodomain inhibition [GRO-Seq]

(Submitter supplied) BET bromodomain inhibition (BETi) abrogates cancer cell growth by disrupting oncogenic gene expression. BRD4 loading at enhancers has been suggested to mediate pause-release and underlie the selective transcriptional response to BETi. Here, we utilized GRO-seq coupled with ChIP-seq to assess the association between gene control elements and the transcriptional response to BETi. Genes immediately down-regulated by BETi display a marked pause-release defect with a minimal impact on transcript elongation within the gene body. more...
Organism:
Homo sapiens
Type:
Other; Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT, WIG
Series
Accession:
GSE70449
ID:
200070449

Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
11814 Series
336528 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

LP-1_500nM_JQ1_30min_GRO-seq_rep2

Organism:
Homo sapiens
Source name:
LP-1_500nM_JQ1_30min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755014
ID:
301755014

SRA Run Selector

4.

LP-1_500nM_JQ1_10min_GRO-seq_rep2

Organism:
Homo sapiens
Source name:
LP-1_500nM_JQ1_10min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755013
ID:
301755013

SRA Run Selector

5.

LP-1_DMSO_10min_GRO-seq_rep2

Organism:
Homo sapiens
Source name:
LP-1_DMSO_10min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755012
ID:
301755012

SRA Run Selector

6.

LP-1_500nM_JQ1_30min_GRO-seq_rep1

Organism:
Homo sapiens
Source name:
LP-1_500nM_JQ1_30min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755011
ID:
301755011

SRA Run Selector

7.

LP-1_500nM_JQ1_10min_GRO-seq_rep1

Organism:
Homo sapiens
Source name:
LP-1_500nM_JQ1_10min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755010
ID:
301755010

SRA Run Selector

8.

LP-1_DMSO_10min_GRO-seq_rep1

Organism:
Homo sapiens
Source name:
LP-1_DMSO_10min
Platform:
GPL16791
Series:
GSE70449 GSE70450
Download data: WIG
Sample
Accession:
GSM1755009
ID:
301755009

SRA Run Selector

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