GSM1085732[Accession] - GEO DataSets

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Items: 4

Select item 2000449311.

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16043 GPL11154
31 Samples

Download data: CEL, WIG

Series

Accession:: GSE44931

ID:: 200044931

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000423552.

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers [ChIP-seq]

(Submitter supplied) Chromatin regulators have become highly attractive targets for cancer therapy, yet many of these regulators are expressed in a broad range of healthy cells and contribute generally to gene expression. An important conundrum has thus emerged: how can inhibition of a general regulator of gene expression produce selective effects at specific oncogenes? Here we investigate how inhibition of the transcriptional coactivator BRD4 (Bromodomain containing 4) leads to selective inhibition of disease-critical oncogenes in a highly malignant blood cancer, multiple myeloma (MM). more...