GSM1099034[Accession] - GEO DataSets

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Items: 4

Select item 2000452031.

Amplitude modulation of androgen signaling by c-MYC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL11154
9 Samples

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Series

Accession:: GSE45203

ID:: 200045203

PubMed Full text in PMC Similar studies

Select item 2000452012.

Amplitude modulation of androgen signaling by c-MYC [ChIP-Seq]

(Submitter supplied) Androgen-stimulated growth of the molecular apocrine breast cancer is mediated by an androgen receptor (AR)-regulated transcriptional program. Through profiling the genomic licalizations of AR and its co-regulators FOXA1 and TCF7L2 in MDA-MB-453 breast cancer cells, we revealed the molecular details of the AR-centered regulatory network. We further identified that c-MYC is a key downstream target co-regulated by AR, FOXA1 and TCF7L2, and reinforces the transctiopnal activation of androgen-responsive genes in this subtype of breast cancers.