GSM1116662[Accession] - GEO DataSets

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Items: 4

Select item 2000458531.

Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16980
33 Samples

Download data: CEL

Series

Accession:: GSE45853

ID:: 200045853

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000458522.

Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]

(Submitter supplied) A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through integrated chemical-genetic analyses, we find that a dominant transcriptional effect of blocking protein translation in cancer cells is complete inactivation of heat shock factor 1 (HSF1), a multifaceted transcriptional regulator of the heat-shock response and many other cellular processes essential for tumorigenesis. more...