GSM1122658[Accession] - GEO DataSets

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Items: 4

Select item 2000460731.

Gene expression and genome-wide location analysis of breast cancer cell-lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL11154
41 Samples

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Accession:: GSE46073

ID:: 200046073

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000460552.

Genome-wide location analysis in breast cancer cell-lines

(Submitter supplied) Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorigenesis. However, the functional relevance of these mutations remains unknown. Here we show that the JARID1B histone H3 lysine 4 demethylase is frequently amplified and overexpressed in luminal breast tumors and a somatic point mutation of JARID1B leads to the gain of luminal-specific gene expression programs. more...