GSM1151051[Accession] - GEO DataSets

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Items: 4

Select item 2000476781.

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9115 GPL11154
22 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE47678

ID:: 200047678

PubMed Full text in PMC Similar studies

Select item 2000474882.

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition [RNA-Seq]

(Submitter supplied) Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely understood. Here, we show that DNA methylation is enriched in included alternatively spliced exons (ASEs) and inhibiting DNA methylation results in aberrant splicing of ASEs. more...