GSM1159901[Accession] - GEO DataSets

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Items: 4

Select item 2000478071.

LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: BED, BEDGRAPH, TXT

Series

Accession:: GSE47807

ID:: 200047807

PubMed Full text in PMC Similar studies

Select item 2000478062.

LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II]

(Submitter supplied) While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. more...