GSM1163059[Accession] - GEO DataSets

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Items: 4

Select item 2000479651.

Environmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL1261
96 Samples

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Series

Accession:: GSE47965

ID:: 200047965

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000479442.

Environmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [RNA-Seq]

(Submitter supplied) Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activating ligands reduced inflammation in the lesional skin of psoriasis patients, whereas AhR antagonists upregulated inflammation. more...