GSM1176707[Accession] - GEO DataSets

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Items: 4

Select item 2000483791.

SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL10558 GPL11154
35 Samples

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Series

Accession:: GSE48379

ID:: 200048379

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000483742.

SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (ChIP-seq)

(Submitter supplied) In addition to the glucocorticoids, the glucocorticoid receptor (GR) is regulated by post-translational modifications, including SUMOylation. We have analyzed how SUMOylation influences the activity of endogenous GR target genes and the receptor chromatin binding by using isogenic HEK293 cells expressing wild-type GR (wtGR) or SUMOylation-defective GR (GR3KR). Gene expression profiling revealed that both dexamethasone up- and down-regulated genes are affected by the GR sumoylation and that the affected genes are significantly associated with pathways of cellular proliferation and survival. more...