GSM1207919[Accession] - GEO DataSets - NCBI

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Items: 4

Select item 2000498331.

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [RNA-seq]

(Submitter supplied) We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level increases. TET1-FL-induced 5hmC accumulates at CGI edges, while TET1 knockdown induces methylation spreading from methylated edges into hypomethylated CGIs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
5 Samples

Download data: TXT

Series

Accession:: GSE49833

ID:: 200049833

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000440392.

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL16686 GPL9115 GPL11154
25 Samples

Download data: CEL, TXT

Series

Accession:: GSE44039

ID:: 200044039

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10422 Series
180547 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3012079194.

Organism:: Homo sapiens

Source name:: HEK293T cell

Platform:: GPL11154
Series:: GSE44039 GSE49833

Download data: TXT

Sample

Accession:: GSM1207919

ID:: 301207919

SRA Run Selector

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GSM1207919[Accession] (4)
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