GSM1296820[Accession] - GEO DataSets

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Items: 4

Select item 2000549601.

Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
53 Samples

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Accession:: GSE54960

ID:: 200054960

PubMed Similar studies

Select item 2000536102.

Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells [human]

(Submitter supplied) Stable maintenance of gene regulatory programs is essential for normal function in multi-cellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are hypothesized to facilitate such maintenance by creating cellular memory that can be written during embryonic development and then guide cell-type specific gene expression. Here we use new methods to study distributions of DNA methylation patterns within cell populations to show that embryonic stem cells preserve their epigenetic state by balancing antagonistic processes that add and remove methylation marks rather than by copying epigenetic information from mother to daughter cells. more...