GSM1338307[Accession] - GEO DataSets

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Items: 4

Select item 2000554261.

Domains of genomewide gene expression dysregulation in Down syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms
42 Samples

Download data: BW, PAIR, TXT

Series

Accession:: GSE55426

ID:: 200055426

Select item 2000554252.

Domains of genomewide gene expression dysregulation in Down syndrome [Dnase HS mapping]

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...