GSM1364028[Accession] - GEO DataSets

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Items: 4

Select item 2000565691.

Critical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791 GPL10999
23 Samples

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Accession:: GSE56569

ID:: 200056569

PubMed Full text in PMC Similar studies

Select item 2000565672.

Critical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (Chip-Seq)

(Submitter supplied) We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed during the generation of iPSCs and contributed to reprogramming. When the generation of iPSCs was completed, LTRs were re-suppressed to levels similar to those in human ES cells. more...