GSM1409327[Accession] - GEO DataSets

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Items: 4

Select item 2000583771.

SMO variants explain the majority of drug resistance in basal cell carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL15520 GPL16791
107 Samples

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Accession:: GSE58377

ID:: 200058377

PubMed Full text in PMC Similar studies

Select item 2000583742.

SMO variants explain the majority of drug resistance in basal cell carcinoma [exome-seq]

(Submitter supplied) Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms, providing a unique opportunity to study human tumor evolution. Here, we identify SMO mutations in 50% (22/44) of resistant BCCs compared with 5.6% (2/36) of untreated BCCs (p<0.0001), and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. more...