GSM1427145[Accession] - GEO DataSets

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Items: 4

Select item 2000590901.

ChIP-seq and RNA-seq analysis of PRC2 core subunits in primary human erythroid progenitor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
30 Samples

Download data: BED, RPKM, WIG

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Accession:: GSE59090

ID:: 200059090

PubMed Full text in PMC Similar studies

Select item 2000590892.

RNA-seq transcriptional profiling in primary human erythroid progenitor cells upon shRNA-mediated knockdown of PRC2 core subunits

(Submitter supplied) Polycomb Repressive Complex 2 (PRC2) plays crucial roles in transcriptional regulation and stem cell development. However, the context-specific functions associated with alternative subunits remain largely unexplored. Here we show that the related enzymatic subunits EZH1 and EZH2 undergo an expression switch during hematopoiesis. We examine the in vivo stoichiometry of the PRC2 complexes by quantitative proteomics and reveal the existence of an EZH1-SUZ12 sub-complex lacking EED. more...