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Items: 3

1.

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma

(Submitter supplied) Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls post-transcriptional dynamics of key mRNA species including those encoding BCL6, MYC and BCL2. Using a proteomics approach, we found that Hsp90 binds to and maintains activity of eIF4E (eukaryotic translation initiation factor 4E). EIF4E drives nuclear export and translation of BCL6, MYC and BCL2 mRNA. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
10 Samples
Download data: TXT
Series
Accession:
GSE63265
ID:
200063265

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
11886 Series
340700 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

PDX4_CON2

Organism:
Homo sapiens
Source name:
De-identified patient derived xenograft, passage 4
Platform:
GPL16791
Series:
GSE63265
Download data
Sample
Accession:
GSM1544681
ID:
301544681

SRA Run Selector

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db=gds|term=GSM1544681[Accession]|query=1|qty=2|blobid=MCID_666ffcc5ce9c6e4cac1de2e5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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