GSM1563748[Accession] - GEO DataSets

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Items: 4

Select item 2000640721.

Genome-wide maps of chromatin state in LATS2-knockout HeLa-S3 cell

(Submitter supplied) Chromatin modifying activities for construction of appropriate epigenetic landscapes by polycomb repressive complex 2 (PRC2) play an essential role in development and tumorigenesis. However, the spatiotemporal mechanisms by which PRC2 achieves diverse epigenomes for specific tissue or cellular contexts remain poorly understood. Here, we discovered that LATS2 knockout causes dysregulation of PRC2 and subsequent transcriptome changes for differentiation in both mouse and human cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

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Series

Accession:: GSE64072

ID:: 200064072

PubMed Full text in PMC Similar studies

Select item 2000635382.

LATS2 regulates repressive epigenetic integrity via regulation of Polycomb repressive complex 2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Expression profiling by array; Non-coding RNA profiling by array; Genome binding/occupancy profiling by high throughput sequencing