GSM1566565[Accession] - GEO DataSets

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Items: 4

Select item 2000642241.

The activation of IL-1 induced enhancers depends on TAK1 kinase activity and NF-KB p65

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL4133 GPL6480
44 Samples

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Accession:: GSE64224

ID:: 200064224

PubMed Full text in PMC Similar studies

Select item 2000642232.

The activation of IL-1 induced enhancers depends on TAK1 kinase activity and NF-KB p65 [ChIP-Seq]

(Submitter supplied) The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-κB subunit p65 in relation to active enhancers and promoters of transcribed genes by ChIP-seq experiments. Out of 35,000 active enhancer regions, 410 H3K4me1-positive enhancers show interleukin (IL)-1-induced H3K27ac and p65 binding. more...