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Items: 3

1.

shRNA knockdown of YAP1 in HCC364 cells, various drug conditions

(Submitter supplied) Through a genetic screen in BRAF mutant tumor cells, we show that the Hippo pathway effector YAP acts as a parallel survival input to promote resistance to RAF-MEK inhibitor therapy. Our data uncover YAP as a novel mechanism of resistance to RAF-MEK targeted therapy. The findings unveil the synthetic lethality of YAP and RAF-MEK co-suppression as a promising strategy to enhance response and patient survival.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
9 Samples
Download data: TXT
Series
Accession:
GSE64550
ID:
200064550

Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
11886 Series
340700 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

hcc364_shY13_tra

Organism:
Homo sapiens
Source name:
HCC364 cells, infected with shRNA against YAP1 & treated with Trametinib
Platform:
GPL16791
Series:
GSE64550
Download data: TXT
Sample
Accession:
GSM1574064
ID:
301574064

SRA Run Selector

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db=gds|term=GSM1574064[Accession]|query=1|qty=2|blobid=MCID_667038e9ce9c6e4cac24a192|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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