GSM1820111[Accession] - GEO DataSets

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Items: 4

Select item 2000708751.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; SNP genotyping by SNP array

Platforms:: GPL14157 GPL16791
16 Samples

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Accession:: GSE70875

ID:: 200070875

PubMed Similar studies

Select item 2000708282.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival [BeadChip]

(Submitter supplied) The potential safety issues related to the acquisition of common genomic aberrations in hPSC cultures are well-recognized, but these risks have not been evaluated for sporadic mutations. Here, we explore whether a sporadic mutation that spontaneously arose in a hESC culture consisting of a single-copy deletion of chr17p13.1 would confer a survival advantage to the mutant cells. Compared to wild-type cells with two normal copies of the chr17p13.1 region, the mutant cells displayed a selective advantage when exposed to stressful conditions, and retained a higher percentage of pluripotent cells after two weeks of in vitro differentiation. more...