GSM1910998[Accession] - GEO DataSets

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Items: 4

Select item 2000689781.

Activation of proto-oncogenes by disruption of chromosome neighborhoods

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL11154 GPL16791 GPL15520
22 Samples

Download data: BED12, WIG

Series

Accession:: GSE68978

ID:: 200068978

PubMed Full text in PMC Similar studies

Select item 2000689762.

Activation of proto-oncogenes by disruption of chromosome neighborhoods [ChIP-Seq]

(Submitter supplied) Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. more...