GSM5722924[Accession] - GEO DataSets

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Items: 4

Select item 2001903971.

Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by array; SNP genotyping by SNP array; Genome variation profiling by high throughput sequencing

Platforms:: GPL11154 GPL31039 GPL18952
194 Samples

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Accession:: GSE190397

ID:: 200190397

Select item 2001903922.

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios [Omni2.5]

(Submitter supplied) Recurring genetic abnormalities have been identified in Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). Among them, IKZF1 deletion was associated with poor prognosis in patients treated with imatinib-based or dasatinib-based regimens. However, the molecular determinants for clinical outcomes in ponatinib-treated patients remain unknown. We systematically analyzed genetic alterations in adults with Ph-positive ALL uniformly treated in clinical trials with dasatinib-based regimens or a ponatinib-based regimen and investigated the molecular determinants for treatment outcomes using pretreatment specimens collected from adults with Ph-positive ALL treated with Hyper-CVAD plus dasatinib or ponatinib. more...