GSM722171[Accession] - GEO DataSets

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Items: 4

Select item 2000291811.

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T-cell acute lymphoblastic leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL13232 GPL9115
64 Samples

Download data: CEL, WIG, YLF

Series

Accession:: GSE29181

ID:: 200029181

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000291802.

ChIP-Seq of TAL1 and its regulatory partners in T-ALL cells

(Submitter supplied) The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1, LMO2, GATA3 and RUNX1 in T-ALL cells. We show that TAL1 forms an interconnected auto-regulatory loop with its partners, and that the TAL1 complex directly activates the MYB oncogene, forming a feed-forward positive regulatory loop that further promotes the TAL1-regulated oncogenic program. more...